The film follows the writer and performer as he underwent gender
reassignment surgery in 2008, removing his breasts but not his
female genitalia.
Speaking to Winfrey, he said the change had affected all his
relationships - not least his long-term partnership with Jennifer
Elia.
"We had to really almost re-learn how to communicate and how to be
around each other." Bono said. "Suddenly (things) didn't mean the
same thing to her. And so we really had to, you know, adjust our --
how we did things and relearn how to be together."
The documentary features gay icon Cher discussing the initial
struggle of dealing with her daughter becoming a son. In it she
admits that she spent months avoiding her son as he went through
the process and had trouble dealing with the sex change.
She also candidly details that she so was afraid she might not
recognise her child that she kept putting off meeting him.
"I'm so terrified of what will happen. If I don't recognise her,
what will happen," she said, adding that it was her daughter's
voice she would miss the most.
Watching the film at her Malibu home over the weekend, insiders
said the disco star has finally come to terms with her child's
transformation and has told friends she admired her son's
courage.
Born in 1969 as the only daughter of the famous couple, Bono was
christened Chastity and often appeared on the famous couple's TV
shows during the seventies.
Later, he felt trapped in the wrong body.
"It was just horrifying to me," Bono told Oprah. "You have this
image of yourself and all of a sudden your body does the exact
opposite of what you feel," he said.